Application of Partial Pressure of Oxygen Control Method in Fast Identification of Intersegmental Plane in Anatomical Sublobar Resection: a Prospective, Randomized Controlled Study

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In recent years, an increasing number of pulmonary nodules have been detected through CT screening. The traditional surgical method for lung cancer is lobectomy combined with lymph node dissection. However, recent studies have demonstrated that sublobar resection for early non-small cell lung cancer (NSCLC) is an effective alternative with the additional benefit of preserving more pulmonary function. However, it also faces many problems, the most prominent of which is the rapid and accurate identification of the intersegmental plane (ISP) during surgery. The modified inflation-deflation method for identifying the ISP is the most commonly used method in anatomical sublobar resection. Nevertheless, the lengthy waiting periods and the lack of clear delineation represent significant challenges in clinical practice. The Partial pressure of Oxygen Control method facilitates the efficient determination of the ISP by reducing the oxygen inhalation concentration and ventilator ventilation time during surgery. This results in a reduced PaO2 in arterial blood, thereby accelerating the rapid appearance of the ISP. Thus, the investigators conducted a prospective, randomized, controlled trial to ascertain whether the oxygen partial pressure control method affects the occurrence time of the ISP and PaO2 during one-lung ventilation, in comparison to the modified inflation-deflation method. Furthermore, the objective was to confirm the safety and efficacy of Partial pressure of Oxygen Control method.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Between the ages of 18 and 75;

• Gender unlimited;

• Eastern Cooperative Oncology Group(ECOG) Performance status(PS) score 0-1 points;

• Thin slice CT indicates that the maximum tumor diameter is ≤ 2.0cm and 0 ≤ CTR\<1.0; (Consolidation Tumor Ratio,CTR)

• Those who voluntarily sign the informed consent form for research can comply with the requirements of the research visit plan and other protocols.

Locations
Other Locations
China
The Second Affiliated Hospital of the Air Force Medical University of PLA
RECRUITING
Xi'an
Contact Information
Primary
Xiaolong Yan, MD
yanxiaolong@fmmu.edu.cn
15991269383
Backup
Mingliang Xing
312596733@QQ.COM
15129745755
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2024-12-30
Participants
Target number of participants: 60
Treatments
Experimental: Partial pressure of Oxygen Control method
After the targeted structures were successfully dissected, the anesthesiologist manually controls pure oxygen one-lung ventilation on the surgical side until the lung is fully expand. The ventilator is disconnected, the airway is opened, and the operator uses a gauze ball to pressure the preserve lung tissue. At a SpO2 of 95%, the healthy side undergoes one-lung ventilation.
No_intervention: Modified inflation-deflation method
After the targeted structures were successfully dissected, and then the collapsed lung was re-expanded completely with controlled airway pressure under 20 cmH2O, with the bronchus of the operation side open to atmosphere while continuing ventilation of the contralateral lung.
Sponsors
Leads: Tang-Du Hospital

This content was sourced from clinicaltrials.gov